Jidol-AP
JIDOL®AP
Tablets
Composition:
Each JIDOL®-AP film
coated tablet contain aceclofenac 100 mg and Paracetamol 500 mg
Description: JIDOL®-AP
is a combination of aceclofenac and paracetamol.
Aceclofenac is an NSAID, It directly blocks PGE 2 secretion at the site of
inflammation by inhibiting IL-beta and TNF in the inflammatory cells.
Aceclofenac has been demonstrated to inhibit cyclooxygenase (COX) activity and
to suppress the PGE 2 production by inflammatory cells. Paracetamol is an
acetaminophen derivative with analgesic, antipyretic properties.
Indications: JIDOL®-AP
is indicated for the
relief of symptoms of
Acute musculoskeletal
painful conditions in adults
Low back pain
Acute flares of RA
& OA
Painful and inflammatory
ENT conditions (Pharyngitis & tonsillitis)
Post-operative pain
Gynaecological pain
e.g. Dysmenorrhoea
Dental pain
Fractures
Dosage: JIDOL®-AP tablets are supplied for oral administration in adults.
The maximum recommended
dose of JIDOL®-AP is two tablets daily, taken as one tablet in the morning and one in the
evening.
Contraindications: Aceclofenac
should not be administered to patients hypersensitive to aceclofenac or other
NSAIDs or patient with a history of aspirin or NSAIDs related allergic or
anaphylactic reactions or with peptic ulcers or GI bleeding, moderate or severe
renal impairment
Side
effects: Most of the adverse
events are minor and reversible with treatment
discontinuation. The
majority of side effects are related to gastrointestinal system
(dyspepsia, abdominal
pain, nausea and diarrhea), most frequent being
dyspepsia, abdominal pain
and rise in hepatic enzymes. Other rare side-effects
include dizziness,
constipation, vomiting, ulcerative stomatitis, rash, dermatitis,
headache, fatigue,
allergic reactions, anemia, granulocytopenia,
thrombocytopenia,
neutropenia, oedema, palpitation, leg cramps, flushing,
purpura, paraesthesia,
tremors, gastrointestinal bleeding, gastrointestinal
ulceration, pancreatitis,
interstitial nephritis, depression, abnormal dreaming,
somnolence, insomnia,
vasculitis, hypoglycemia, rise in blood urea, serum
creatinine and serum
potassium. As with other NSAIDs, severe mucocutaneous
skin reactions may also occur with JIDOL®-AP.
Drug
interaction: Drug interactions
associated with Aceclofenac are similar to those observed with
other NSAIDs. Aceclofenac
may increase the plasma concentrations of lithium,
digoxin and methotrexate.
It may increase the activity of anticoagulants, inhibit
the activity of
diuretics, enhance cyclosporine nehrotoxicity and precipitate
convulsions when co-administered
with quinolone antibiotics. Co-administration of
Aceclofenac with other
NSAIDs and corticosteroids are to be avoided due to
increased incidence of
side-effects.
The risk of Paracetamol
toxicity may be increased in patients receiving other
potentially hepatotoxic
drugs or drugs that induce hepatic microsomal enzymes.
Coadministration of
Paracetamol with rifampicin, isoniazid, chloramphenicol, antiepileptic
drugs and antiviral drugs
is to be avoided. Metoclopromide may
increase the absorption
of Paracetamol whereas excretion and plasma
concentration may be
altered when coadministered with probenecid.
Cholestyramine also reduces the absorption of
Paracetamol
Precautions: JIDOL®-AP
may cause dizziness. Driving or operating machinery are to be
avoided.
Individuals receiving
long-term treatment should be regularly monitored for renal
function tests, liver
function tests and blood counts. It is to be used with caution
in hepatic porphyria,
coagulation disorders, history of peptic ulcers, ulcerative
colitis, Crohn’s disease,
SLE, cerebrovascular bleeding, pregnancy and lactation.
Caution should be
exercised in patients with mild to moderate impairment of
cardiac, hepatic or renal
function and in elderly patients who are more likely to be
suffering from these
conditions. Caution is also required in patients on diuretic
therapy or otherwise at risk of hypovolemia.
Presentation: JIDOL®-AP
tablets
are available in blister strip of 10's. 10 such strips in a carton.
Disclaimer:
The above information is for general understanding of the visitor. Please
consult a registered medical practitioner before taking the aforesaid medicine.